A Concise, Efficient and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-(-)-Carvone.

Scalable Synthesis of (−)-Thapsigargin

Total syntheses of the complex, highly oxygenated sesquiterpenes thapsigargin (1) and nortrilobolide (2) are presented. Access to analogues of these promising bioactive natural products has been limited to tedious isolation and semisynthetic efforts. Elegant prior total syntheses demonstrated the feasibility of creating these entitites in 36-42 step processes. The currently reported route proce...

A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F.

A Tandem Scalable Microwave-Assisted Williamson Alkyl Aryl Ether Synthesis under Mild Conditions

An efficient tandem synthesis of alkyl aryl ethers, including valuable building blocks of dialdehyde and dinitro groups under microwave irradiation and solvent free conditions on potassium carbonate as a mild solid base has been developed. A series of alkyl aryl ethers were obtained from alcohols in excellent yields by following the Williamson ether synthesis protocol under practical mild condi...

Effect of ultrasound on the production of Carvone as a secondary metabolite in callus derived from Bunium persicum Boiss.

Background & Aim: Medicinal plants are most valuable and useful sources as productive factors of drugs. Production and extraction of secondary metabolites have a huge economical importance in recent years. Carvone is a compound in Bunium persicum fruit and shoot and, it is one of the wide range varieties of valuable and useful secondary metabolites. Due to limited crop production, usin...

Effect of ultrasound on the production of Carvone as a secondary metabolite in callus derived from Bunium persicum Boiss.

Background & Aim: Medicinal plants are most valuable and useful sources as productive factors of drugs. Production and extraction of secondary metabolites have a huge economical importance in recent years. Carvone is a compound in Bunium persicum fruit and shoot and, it is one of the wide range varieties of valuable and useful secondary metabolites. Due to limited crop production, usin...